10.6084/m9.figshare.5114020.v1
Saia-Cereda V.M.
Saia-Cereda
V.M.
Santana A.G.
Santana
A.G.
Schmitt A.
Schmitt
A.
Falkai P.
Falkai
P.
Martins-de-Souza D.
Martins-de-Souza
D.
Supplementary Material for: The Nuclear Proteome of White and Gray Matter from Schizophrenia Postmortem Brains
Karger Publishers
2017
Schizophrenia
Proteomics
Nucleus
Nuclei
Nuclear proteome
2017-06-16 09:56:20
Dataset
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_The_Nuclear_Proteome_of_White_and_Gray_Matter_from_Schizophrenia_Postmortem_Brains/5114020
<p>Schizophrenia (SCZ) is a serious neuropsychiatric disorder that
manifests through several symptoms from early adulthood. Numerous
studies over the last decades have led to significant advances in
increasing our understanding of the factors involved in SCZ. For
example, mass spectrometry-based proteomic analysis has provided
important insights by uncovering protein dysfunctions inherent to SCZ.
Here, we present a comprehensive analysis of the nuclear proteome of
postmortem brain tissues from corpus callosum (CC) and anterior temporal
lobe (ATL). We show an overview of the role of deregulated nuclear
proteins in these two main regions of the brain: the first, mostly
composed of glial cells and axons of neurons, and the second,
represented mainly by neuronal cell bodies. These samples were collected
from SCZ patients in an attempt to characterize the role of the nucleus
in the disease process. With the ATL nucleus enrichment, we found 224
proteins present at different levels, and 76 of these were nuclear
proteins. In the CC analysis, we identified 119 present at different
levels, and 24 of these were nuclear proteins. The differentially
expressed nuclear proteins of ATL are mainly associated with the
spliceosome, whereas those of the CC region are associated with
calcium/calmodulin signaling.</p>