10.6084/m9.figshare.5107732.v2
Lili Zhang
Lili
Zhang
Zhengkai Chen
Zhengkai
Chen
Hongli Li
Hongli
Li
Wenguang Yin
Wenguang
Yin
Jianfeng Xu
Jianfeng
Xu
Maozhong Miao
Maozhong
Miao
Hongjun Ren
Hongjun
Ren
Transition metal-free tandem pyridinyl–allyl–allyl cross-coupling reaction
Taylor & Francis Group
2017
Allylation
cross-coupling
metal-free
pyridines
tandem reaction
2017-07-19 15:08:33
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Transition-metal-free_tandem_pyridinyl-allyl-allyl_cross-coupling_reaction/5107732
<p>A transition metal-free, direct one-pot domino allylation reaction of 2-pyridinyl Grignard reagents with polysubstituted allyl chlorides for the regioselective synthesis of pyridinyl-substituted 1,5-diene derivatives has been disclosed. The reaction presumably proceeded through the coupling of polysubstituted allyl chloride to 2-PyMgX, which was <i>in situ</i> generated from 2-bromopyridine with <i>i</i>-PrMgCl·LiCl.</p>