10.6084/m9.figshare.5107732.v2 Lili Zhang Lili Zhang Zhengkai Chen Zhengkai Chen Hongli Li Hongli Li Wenguang Yin Wenguang Yin Jianfeng Xu Jianfeng Xu Maozhong Miao Maozhong Miao Hongjun Ren Hongjun Ren Transition metal-free tandem pyridinyl–allyl–allyl cross-coupling reaction Taylor & Francis Group 2017 Allylation cross-coupling metal-free pyridines tandem reaction 2017-07-19 15:08:33 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Transition-metal-free_tandem_pyridinyl-allyl-allyl_cross-coupling_reaction/5107732 <p>A transition metal-free, direct one-pot domino allylation reaction of 2-pyridinyl Grignard reagents with polysubstituted allyl chlorides for the regioselective synthesis of pyridinyl-substituted 1,5-diene derivatives has been disclosed. The reaction presumably proceeded through the coupling of polysubstituted allyl chloride to 2-PyMgX, which was <i>in situ</i> generated from 2-bromopyridine with <i>i</i>-PrMgCl·LiCl.</p>