TY - DATA T1 - Additional file 1: of YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies PY - 2017/06/09 AU - Marta Querol-Vilaseca AU - Martí Colom-Cadena AU - Jordi Pegueroles AU - Carla San Martín-Paniello AU - Jordi Clarimon AU - Olivia Belbin AU - Juan Fortea AU - Alberto Lleó UR - https://springernature.figshare.com/articles/figure/Additional_file_1_of_YKL-40_Chitinase_3-like_I_is_expressed_in_a_subset_of_astrocytes_in_Alzheimer_s_disease_and_other_tauopathies/5099341 DO - 10.6084/m9.figshare.c.3800161_D1.v1 L4 - https://ndownloader.figshare.com/files/8649457 KW - YKL-40 KW - Alzheimer’s disease KW - Tauopathies KW - Tau KW - Astrocytes KW - Neuroinflammation N2 - Figure S1. Semi-automated method for pathological burden quantification. For all conditions tau and GFAP were assessed using a randomized computer-based quantification of patterns and severity in immunohistochemical stains. Cortical grey matter of each case was delimited blinded to clinical phenotypes (A). We developed an in-house algorithm that allows defining randomized regions of interest (ROIs) on a full-section scan (B–C), to compute density of protein expression (D) and to quantify the number of pathological objects (E). (TIF 4423 kb) ER -