10.1371/journal.pone.0179162.g005 Yue Yang Yue Yang Yang Wang Yang Wang Yawei Kong Yawei Kong Xiaoning Zhang Xiaoning Zhang Lunhao Bai Lunhao Bai Western blotting results in each group. Public Library of Science 2017 OAG 2A 60 min treadmill exercise MMP OAE groups OAE 3 group treadmill exercise articular cartilage degeneration treadmill exercise program COL OAE groups vs ELISA CG frequency treadmill exercise frequencies treadmill exercise rest interval intra-articular lavage fluid articular cartilage NF -κB p 65 monosodium iodoacetate-induced osteoarthritis LXA 4 TNF IL monosodium iodoacetate-induced OA 2017-06-08 17:55:18 Figure https://plos.figshare.com/articles/figure/Western_blotting_results_in_each_group_/5095339 <p>Effect of different frequency with same amount of treadmill exercise on the expression of MMP-13, TIMP-1, NF-κB p65, IκB-β, and COL2A1 expression in knee joint cartilage of rats with MIA-induced OA. Protein expression was determined in western blots of total protein extracted from cartilage tissues as described in Materials and Methods. The data was obtained in three separate experiments β-actin as an internal standard. Differences between CG and the OAG group were significant (*<i>P</i> < 0.001), and differences between the OAG and the treadmill frequency groups were significant (<sup>+</sup><i>P</i><0.001, <sup>+a</sup><i>P</i> = 0.030, <sup>+b</sup><i>P</i> = 0.001, <sup>+c</sup><i>P</i> = 0.039, <sup>+d</sup><i>P</i> = 0.010, <sup>+e</sup><i>P</i> = 0.038, <sup>+f</sup><i>P</i> = 0.002,). One-way ANOVA, n = 3 rats for each group, means with 95% confidence interval.</p>