%0 Generic %A Liu, Kun %A He, Kun %A Xue, Ting %A Liu, Ping %A Xu, Lisa X. %D 2017 %T The cryo-thermal therapy-induced IL-6-rich acute pro-inflammatory response promoted DCs phenotypic maturation as the prerequisite to CD4+ T cell differentiation %U https://tandf.figshare.com/articles/dataset/The_cryo-thermal_therapy-induced_IL-6-rich_acute_pro-inflammatory_response_promoted_DCs_phenotypic_maturation_as_the_prerequisite_to_CD4_sup_sup_T_cell_differentiation/5085085 %R 10.6084/m9.figshare.5085085.v1 %2 https://ndownloader.figshare.com/files/8618569 %2 https://ndownloader.figshare.com/files/8618572 %K Acute inflammation %K interleukine-6 %K DCs maturation %K anti-tumour immune response %X

In our previous studies, a novel tumour therapeutic modality of the cryo-thermal therapy has been developed leading to long-term survival in 4T1 murine mammary carcinoma model. The cryo-thermal therapy induced the strong acute inflammatory response and IL-6 was identified in an acute profile. In this study, we found that the cryo-thermal therapy triggered robust acute inflammatory response with high expression of IL-6 locally and systemically. The phenotypic maturation of dendritic cells (DCs) was induced by acute IL-6 following the treatment. The mature DCs promoted CD4+ T cell differentiation. Moreover, the production of interferon γ (IFN γ) in the serum and CD4+ T cells were both abrogated by IL-6 neutralisation following the treatment. Our findings revealed that the cryo-thermal therapy-induced acute IL-6 played an important role in initiating the cascading innate and adaptive anti-tumour immune responses, resulting in CD4+ T cell differentiation. It would be interesting to investigate acute IL-6 as an early indicator in predicating tumour therapeutic effect.

%I Taylor & Francis