10.1371/journal.pbio.1000456.g007
Majid Kazemian
Majid
Kazemian
Charles Blatti
Charles
Blatti
Adam Richards
Adam
Richards
Michael McCutchan
Michael
McCutchan
Noriko Wakabayashi-Ito
Noriko
Wakabayashi-Ito
Ann S. Hammonds
Ann
S. Hammonds
Susan E. Celniker
Susan
E. Celniker
Sudhir Kumar
Sudhir
Kumar
Scot A. Wolfe
Scot
A. Wolfe
Michael H. Brodsky
Michael
H. Brodsky
Saurabh Sinha
Saurabh
Sinha
Examples of how maternal and gap patterned TFs together give rise to patterned expression.
Public Library of Science
2010
maternal
patterned
tfs
2010-08-17 02:01:52
Figure
https://plos.figshare.com/articles/figure/_Examples_of_how_maternal_and_gap_patterned_TFs_together_give_rise_to_patterned_expression_/507312
<p>Shown are nine sample CRMs, their expression domains (in pink) along the A/P axis (left: anterior), their regulators (as per the predicted regulatory network of <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000456#pbio-1000456-g006" target="_blank">Figure 6B</a>), and their respective expression domains (in color code matching that of <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000456#pbio-1000456-g006" target="_blank">Figure 6B</a>). Arrows indicate activation and barred lines indicate repressive influence. Repressor domains shown are required to be overlapping with an activator's domain of influence. Solid edges indicate that the regulatory influence is supported by previous experimental evidence in the literature, while dashed edges indicate novel interactions. Labels of TF expression domains are in black or white for better color contrast and have no semantic difference. *The edge between DSTAT and <i>eve_stripe5</i> is not based on our model predictions (since DSTAT is broadly expressed and was not included in the model) but on the presence of DSTAT binding sites (motif score greater than 4 standard deviations above genomic mean) in the CRM.</p>