%0 Figure %A Dillinger, Stefan %A Straub, Tobias %A Németh, Attila %D 2017 %T Comparative genomics of NADs, iNADs, lamina-associated domains (LADs) and inter-LADs (iLADs) uncovers NAD-specific genomic features. %U https://plos.figshare.com/articles/figure/Comparative_genomics_of_NADs_iNADs_lamina-associated_domains_LADs_and_inter-LADs_iLADs_uncovers_NAD-specific_genomic_features_/5070595 %R 10.1371/journal.pone.0178821.g003 %2 https://ndownloader.figshare.com/files/8585008 %K NAD %K interphase chromosome contacts %K interphase chromosome organization %K chromosomal domains %K 100 kb %K nucleolar association %K reorganisation Mammalian chromosomes %K Nucleolus association %K minute changes %K immunofluorescence analyses %K Mb %K senescent cells %K pericentromeric satellite %K contact probabilities %K chromatin modification patterns %K use nucleolus genomics %K gene expression levels %K Genome-wide mapping %K 3 D genome structure %K perinucleolar space %K genomic organization %K H 3K heterochromatin %K nucleolus-associated chromosomal domains %K Hi-C data analysis %K replication timing %K self-association frequencies %K transcriptional changes %K replicative senescence %X

(A) Venn diagrams and Jaccard coefficients show the extent of overlap between NADs and LADs. LAD1: LADs of Tig3 cells [44], LAD2 and LAD3: LADs of IMR90 cells [24,25]. (B) Bar graphs show Gencode v19 and UniProt gene frequencies in NADs (red), iNADs (grey), LADs (black), and iLADs (white) based on UCSC Table Browser data. (C) RefSeq gene (ZNF, OR and DEF indicate zinc finger, olfactory receptor and defensin gene families, respectively) frequencies in NADs, iNADs, LADs, and iLADs. (D) Non-coding RNA gene (‘RNA genes’) and (E) repeat frequencies in NADs, iNADs, LADs, and iLADs. The SINE repeat bars are divided with a horizontal line into MIR (bottom) and Alu (top) sub-groups.

%I PLOS ONE