Supplementary Material for: Genetic Predictors of ≥5% Weight Loss by Multidisciplinary Advice to Severely Obese Subjects
Aller E.E.J.G.
Mariman E.C.M.
Bouwman F.G.
van Baak M.A.
10.6084/m9.figshare.5065531.v1
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Genetic_Predictors_of_5_Weight_Loss_by_Multidisciplinary_Advice_to_Severely_Obese_Subjects/5065531
<p><b><i>Background:</i></b> Weight loss success is determined by genetic factors, which may differ according to treatment strategy. <b><i>Methods:</i></b>
From a multidisciplinary obesity treatment program involving dietary
advice, psychological counseling, and increased physical activity, 587
subjects (68% female; 46.1 ± 12.4 years; BMI 39.9 ± 6.3) were recruited.
At baseline, a blood sample was drawn for DNA isolation. Genotypes were
determined for 30 polymorphisms in 25 candidate genes. The association
between genotypes and weight loss was assessed after 3 months
(short-term) and after 12 months of treatment (long-term). Weight loss
was categorized as ≥5% or <5% of initial weight. <b><i>Results:</i></b>
The G/G genotype of PLIN1 (rs2289487) and PLIN1 (rs2304795), the T/T
genotype of PLIN1 (rs1052700), and the C/C genotype of MMP2 predicted
≥5% weight loss in the first 3 months. The C/G-G/G genotype of PPARγ
(rs1801282) and the T/C genotype of TIMP4 (rs3755724) predicted ≥5%
weight loss after 12 months. Subjects with the combination of PPARγ
(rs1801282) C/G-G/G and TIMP4 (rs3755724) T/C lost even more weight. <b><i>Conclusion:</i></b>
Polymorphisms in genes related to regulation of fat storage and
structural adaptation of the adipocytes are predictors for weight loss
success with different genes being relevant for short-term and long-term
weight loss success.</p>
2017-06-02 09:09:58
Obesity
Lifestyle intervention
Polymorphisms
Predictors
Weight loss maintenance
Fat storage
Adipocyte adaptation
Extracellular matrix