%0 Generic %A H.W., Lee %A G.H., Choi %A D.Y., Kim %A Y.N., Park %A K.S., Kim %A J.S., Choi %A S.H., Ahn %A K.-H., Han %D 2017 %T Supplementary Material for: Less Fibrotic Burden Differently Affects the Long-Term Outcomes of Hepatocellular Carcinoma after Curative Resection %U https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Less_Fibrotic_Burden_Differently_Affects_the_Long-Term_Outcomes_of_Hepatocellular_Carcinoma_after_Curative_Resection/5057668 %R 10.6084/m9.figshare.5057668.v1 %2 https://ndownloader.figshare.com/files/8560660 %2 https://ndownloader.figshare.com/files/8560663 %2 https://ndownloader.figshare.com/files/8560666 %2 https://ndownloader.figshare.com/files/8560669 %K Hepatocellular carcinoma %K Surgical resection %K Cirrhosis %X

Background: The clinical features of hepatocellular carcinoma (HCC) differ in patients with and without cirrhosis. Objective: We aimed to investigate the long-term outcomes of noncirrhotic HCC patients after curative resection. Methods: We retrospectively examined 649 consecutive patients with HCC who underwent curative resection from 1996 to 2012; 387 (59.6%) were cirrhotic and 262 (40.4%) were noncirrhotic. Results: The mean age was 54.7 years, and 511 (78.7%) of the study participants were men. The most common cause of HCC was hepatitis B virus (n = 419, 64.6%). Noncirrhotic tumors were larger and more advanced than cirrhotic tumors. However, the noncirrhotic group showed better disease-free survival (DFS) and overall survival (OS) after resection than the cirrhotic group (median 64.0 vs. 56.0 months for OS and 48.0 vs. 31.0 months for DFS, p < 0.05). The predictors for HCC recurrence were cirrhosis, tumor number, portal vein invasion, and major surgery. Conclusions: Noncirrhotic HCC showed better DFS and OS after resection than cirrhotic HCC, although noncirrhotic HCC presented more aggressively.

%I Karger Publishers