Chemoselective Access to γ‑Ketoesters with Stereogenic Quaternary α‑Center or γ‑Keto Nitriles by Aerobic Reaction of α-Cyanoesters and Styrenes Song-Lin Zhang Xian-Jin Wang Ze-Long Yu 10.1021/acs.orglett.7b01264.s001 https://acs.figshare.com/articles/journal_contribution/Chemoselective_Access_to_Ketoesters_with_Stereogenic_Quaternary_Center_or_Keto_Nitriles_by_Aerobic_Reaction_of_-Cyanoesters_and_Styrenes/5053747 Chemoselective access to either γ-ketoesters with a quaternary all-carbon α-stereogenic center or γ-keto nitriles is described by copper-catalyzed aerobic reaction of styrenes with α-cyanoesters. Formal oxo-enolation or oxo-cyanomethylation of styrenes is achieved via a sequence of addition of enolate (or cyanomethyl) radical to olefin and oxidation of the resulting radical adduct. This method starts from abundant and cheap feedstock under aerobic conditions, without any prefunctionalization or the production of stoichiometric metal salts waste, making it very attractive for practical use. 2017-05-31 14:20:56 Styrenes Chemoselective access quaternary all-carbon α- stereogenic center γ- ketoesters Aerobic Reaction styrene α- Cyanoesters Formal oxo-enolation γ- keto nitriles Chemoselective Access stoichiometric metal salts waste α- cyanoesters