TY - DATA T1 - Mechanistic Study of Copper-Catalyzed Decarboxylative C–N Cross-Coupling with Hypervalent Iodine Oxidant PY - 2017/05/19 AU - Yi-Nuo Yang AU - Ju-Long Jiang AU - Jing Shi UR - https://acs.figshare.com/articles/dataset/Mechanistic_Study_of_Copper-Catalyzed_Decarboxylative_C_N_Cross-Coupling_with_Hypervalent_Iodine_Oxidant/5026499 DO - 10.1021/acs.organomet.7b00095.s002 L4 - https://ndownloader.figshare.com/files/8487950 KW - reductive elimination KW - proton transfer KW - Mechanistic Study KW - DFT KW - site selectivity KW - site-selective formation KW - electron transfer KW - reaction pathway KW - III KW - Hypervalent Iodine Oxidant Copper-catalyzed KW - hypervalent iodine oxidant KW - proton transfer process KW - bond N2 - Copper-catalyzed directed decarboxylative C–N cross-coupling, which is promoted by a hypervalent iodine oxidant, provides a new strategy for the site-selective formation of aliphatic C–N bonds. Despite the great synthetic potential, the mechanism of this reaction and especially the origin of the radical species still remain controversial. To resolve this problem, herein density functional theory (DFT) calculations have been employed to elucidate the mechanistic details of this reaction. As a result, a comprehensive reaction pathway involving IIII–O bond heterolysis, single electron transfer (SET), hydrogen atom transfer (HAT), decarboxylation, proton transfer, and reductive elimination is reported. Meanwhile, analyzing the necessity of the directing groups in realizing the site selectivity, we found that the chelation of the directing group to the Cu­(III) center can remarkably facilitate the proton transfer process. ER -