Güell, Oriol Sagués, Francesc Serrano, M. Ángeles Dataset for: Detecting the Significant Flux Backbone of <i>Escherichia coli </i>metabolism The heterogeneity of computationally predicted reaction fluxes in metabolic networks within a single flux state can be exploited to detect their significant flux backbone. Here, we disclose the backbone of <i>Escherichia coli</i>, and compare it with the backbones of other bacteria. We find that, in general, the core of the backbones is mainly composed of reactions in energy metabolism corresponding to ancient pathways. In <i>E. coli</i>, the synthesis of nucleotides and the metabolism of lipids form smaller cores which rely critically on energy metabolism. Moreover, the consideration of different media leads to the identification of pathways sensitive to environmental changes. The metabolic backbone of an organism is thus useful to trace simultaneously both its evolution and adaptation fingerprints. Disparity Filter;Metabolic Networks;Metabolic Backbones;Biophysics;Synthetic Biology;Biochemistry;Plant Biology;Virology;Receptors and Membrane Biology;Computational Biology;Immunology;Neuroscience;Cell Development, Proliferation and Death;Molecular Biology;Evolutionary Biology;Signal Transduction;Cancer Cell Biology;Systems Biology;Structural Biology 2017-05-12
    https://wiley.figshare.com/articles/dataset/Dataset_for_Detecting_the_Significant_Flux_Backbone_of_i_Escherichia_coli_i_metabolism/5001869
10.6084/m9.figshare.5001869.v1