10.6084/m9.figshare.4986221.v1
Li J.
Li
J.
Liu L.
Liu
L.
Rui W.
Rui
W.
Li X.
Li
X.
Xuan D.
Xuan
D.
Zheng S.
Zheng
S.
Yu Y.
Yu
Y.
Zhang J.
Zhang
J.
Kong N.
Kong
N.
Zhu X.
Zhu
X.
Zou H.
Zou
H.
Wan W.
Wan
W.
Xue Y.
Xue
Y.
Supplementary Material for: New Interleukins in Psoriasis and Psoriatic Arthritis Patients: The Possible Roles of Interleukin-33 to Interleukin-38 in Disease Activities and Bone Erosions
Karger Publishers
2017
Interleukins
Psoriasis
Psoriatic arthritis
Osteoclast precursors
Psoriasis Area and Severity Index
Psoriatic Arthritis Joint Activity Index
Sharp score
Bath Ankylosing Spondylitis Radiology Index
2017-05-09 09:03:04
Journal contribution
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_New_Interleukins_in_Psoriasis_and_Psoriatic_Arthritis_Patients_The_Possible_Roles_of_Interleukin-33_to_Interleukin-38_in_Disease_Activities_and_Bone_Erosions/4986221
<p><b><i>Objectives:</i></b> New interleukins (ILs), especially members
of IL-1 and IL-12 families, have recently been reported to be involved
in the development and regulation of autoimmune and inflammatory
diseases. In this study, we aimed to explore the impact of these new ILs
in psoriasis (Ps) and psoriatic arthritis (PsA). <b><i>Methods:</i></b>
Forty PsA patients, 20 Ps patients, and 20 healthy controls (HCs) were
recruited. Blood samples were obtained for detecting the levels of ILs,
IL-12/23p40, and tumor necrosis factor α (TNF-α). The severity of skin
lesions was assessed by the Psoriasis Area and Severity Index (PASI).
Arthritis activities of PsA patients were assessed by the PsA Joint
Activity Index. For PsA patients, circulating osteoclastogenesis-related
cytokines (osteoprotegerin and receptor activator of nuclear factor-κB
ligand) and numbers of osteoclast precursors were evaluated.
Radiographic features of affected joints in these patients were scored
for erosion, joint-space narrowing, osteolysis, and new bone formation.
Correlations among levels of these ILs, Ps, and PsA disease activities
and bone erosions were studied. <b><i>Results:</i></b> Ps and PsA
patients had higher serum levels of TNF-α, IL-12/23p40, and IL-33. Serum
levels of IL-34 and IL-35 were higher in PsA patients than in Ps
patients and HCs. Patients with pustular Ps had higher serum levels of
IL-36α and IL-38 than patients with Ps vulgaris or HCs. Increased serum
levels of IL-36α were positively correlated with PASI. <b><i>Conclusion:</i></b>
Certain ILs were elevated in the circulation of patients with Ps and
PsA, which might contribute to the pathogenesis of skin lesions and
arthritis.</p>