%0 DATA
%A Cemal, Cagatay Bilgin
%A Amanda, W. Lund
%A Ali, Can
%A George, E. Plopper
%A Bülent, Yener
%D 2013
%T Outline of the algorithm to compute Collagen Alignment Index (CAI).
%U https://plos.figshare.com/articles/_Outline_of_the_algorithm_to_compute_Collagen_Alignment_Index_CAI_/497814
%R 10.1371/journal.pone.0012783.g007
%2 https://ndownloader.figshare.com/files/827447
%K algorithm
%K compute
%K collagen
%K alignment
%X After segmenting the nuclei, cell-graph are built capturing the spatial distribution. Voronoi diagrams are built and the gradient vectors in each Voronoi compartment are calculated. A distribution of the angles between the cell-graph edges and the gradient vectors is calculated to find the CAI metric.