TY - DATA T1 - MOESM8 of Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer PY - 2017/05/01 AU - Ina Chen AU - Lesley Mathews-Greiner AU - Dandan Li AU - Abisola Abisoye-Ogunniyan AU - Satyajit Ray AU - Yansong Bian AU - Vivek Shukla AU - Xiaohu Zhang AU - Raj Guha AU - Craig Thomas AU - Berkley Gryder AU - Athina Zacharia AU - Joal Beane AU - Sarangan Ravichandran AU - Marc Ferrer AU - Udo Rudloff UR - https://springernature.figshare.com/articles/presentation/MOESM8_of_Transcriptomic_profiling_and_quantitative_high-throughput_qHTS_drug_screening_of_CDH1_deficient_hereditary_diffuse_gastric_cancer_HDGC_cells_identify_treatment_leads_for_familial_gastric_cancer/4959395 DO - 10.6084/m9.figshare.c.3768611_D8.v1 L4 - https://ndownloader.figshare.com/files/8341184 KW - Hereditary diffuse gastric cancer (HDGC) KW - High throughput drug screening KW - Therapeutic leads KW - c.1380delA CDH1 gastric cancer cells KW - Differential gene expression profiling N2 - Additional file 8: Figure S6. A, Target enrichment for compounds with CRC −1.1, −1.2, −2.1, or −2.2 and delta logAC50 (SB.mhdgc-1 logAC50–SB.msgc-1 logAC50) < −1. −log p values were calculated as described in materials and methods based on the total number of compounds targeting a gene or mechanism. B, LogAC50 distributions of compounds that show CRC −1.1, −1.2, −2.1, or −2.1 and logAC50 <−1 organized by enriched target class in c.1380delA CDH1 SB.mhdgc-1 versus SB.msgc-1 gastric cancer cells. Box plots of median logAC50 values of select target classes showing enrichment in c.1380delA CDH1 SB.mhdgc-1 (red plots) and SB.msgc-1 (blue plots). C, Concomitant dysregulation of target genes and selective activity of MIPE compounds in c.1380delA CDH1 SB.mhdgc-1 versus SB.msgc-1 gastric cancer cells. Genes with greater than two-fold expression difference in c.1380delA CDH1 SB.mhdgc-1 compared to SB.msgc-1 cells and which are direct targets of compounds in MIPE Oncology 4 are shown. Genes that are downregulated in c.1380delA CDH1 SB.mhdgc-1 compared to SB.msgc-1 cells are represented by green dots; red dots represent upregulated genes (log10 fold change indicated on the right). Overlaid are boxplots for difference in logAC50 (LAC50) SB.mhdgc-1–SB.msgc-1 for all compounds in MIPE Oncology 4 per target (top) or maximum response (bottom). ER -