TY - DATA T1 - Reproducibility of binding potentials estimated using HYDECA, LEGA, and 2TCM. PY - 2017/05/01 AU - Francesca Zanderigo AU - J. John Mann AU - R. Todd Ogden UR - https://plos.figshare.com/articles/figure/Reproducibility_of_binding_potentials_estimated_using_HYDECA_LEGA_and_2TCM_/4957823 DO - 10.1371/journal.pone.0176636.g006 L4 - https://ndownloader.figshare.com/files/8346272 KW - reference region Background KW - non-ideal reference region KW - impulse response function KW - HYDECA test-retest reproducibility KW - time activity curves KW - deconvolution approach KW - vivo non-displaceable binding KW - tracer metabolite-corrected concentration curve KW - reference region KW - V ND KW - brain PET targets KW - binding potentials BP P KW - Different regions show N2 - Average plus standard deviation (across test-retest pairs of scans within each tracer) test-retest percent difference PDBPP values calculated in each of the considered region for [11C]DASB (left) and [11C]CUMI-101 (right), using BPP based on VND from HYDECA, BPP based on VT-RR,LEGA, BPP calculated directly from the 2TCM kinetic rates, and BPP based on VT-RR,2TCM (top). Corresponding values for the test-retest percent difference PDBPND (bottom). Vertical axes are reported in logarithmic scale to allow for easier visualization of the direct 2TCM results based on 2TCM kinetic rates. Statistically significant comparisons (p-value ≤ 0.05) are indicated. AMY: amygdala; CIN: cingulate; DCA: dorsal caudate; HIP: hippocampus; OCC: occipital lobe; TEM: temporal lobe; VST: ventral striatum; PDBPP: percent difference for BPP; PDBPND: percent difference for BPND; VND: non-displaceable distribution volume; VT-RR,LEGA: tracer total distribution volume in the non-ideal reference region estimated using LEGA; LEGA: Likelihood Estimation in Graphical Analysis; 2TCM: two-tissue compartment model; VT-RR,2TCM: racer total distribution volume in the non-ideal reference region estimated using 2TCM. ER -