Supplementary Material for: Ultraviolet A1 Phototherapy in the Treatment of Early Mycosis Fungoides
Adışen E.
Tektaş V.
Erduran F.
Erdem Ö.
Gürer M.A.
10.6084/m9.figshare.4906739.v1
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Ultraviolet_A1_Phototherapy_in_the_Treatment_of_Early_Mycosis_Fungoides/4906739
<p><b><i>Background:</i></b> Phototherapy has been the mainstay of
therapies for early mycosis fungoides (MF). The beneficial role of
ultraviolet (UV) light on MF is suggested by the observation that
lesions occur on non-sun-exposed areas. Therapeutic light sources that
are available today are broadband UVB, psoralen and UVA, narrowband UVB,
and long-wave UV (UVA1). Current literature provides increasing
evidence on the use of UVA1 to treat MF. <b><i>Aim:</i></b> To investigate the treatment responses of early MF patients treated with fixed 30 J/cm<sup>2</sup> doses of UVA1 phototherapy. <b><i>Material and Methods:</i></b> Nineteen patients with early MF, stage IA-IIA of the TNM staging system, received fixed 30 J/cm<sup>2</sup>
doses of UVA1, given 5 times weekly over 5 weeks. Therapeutic
effectiveness was assessed by clinical examination and was confirmed by
histological evaluation. <b><i>Results:</i></b> Of the 19 patients,
complete responses were achieved in 12 (63%) and partial responses were
achieved in 7 (37%) patients after UVA1 radiation exposures. During the
study, UVA1 therapy was well tolerated. During the follow-up, 7 (58%) of
the 12 patients with complete response relapsed within 3 months of the
UVA1 therapy. <b><i>Conclusion:</i></b> The current study provides clinical and histological evidence for the effectiveness of UVA1 (30 J/cm<sup>2</sup>
5 times a week for 5 weeks) as a skin-directed therapy in the treatment
of early MF; however, such a treatment failed to maintain a long and
sustained response. Thus, studies to identify the optimal dosing
protocol regarding the therapeutic efficacy, the factors affecting
relapse time/rate, and the necessity of maintenance treatment are
needed.</p>
2017-04-25 13:02:10
Ultraviolet A1 phototherapy
Mycosis fungoides
Treatment