10.6084/m9.figshare.4892495.v1 Zahra Bagheri Farahani Zahra Bagheri Farahani Amir Mirzaie Amir Mirzaie Fatemeh Ashrafi Fatemeh Ashrafi Maryam Rahimpour Hesari Maryam Rahimpour Hesari Ali Chitgar Ali Chitgar Hassan Noorbazargan Hassan Noorbazargan Arian Rahimi Arian Rahimi Phytochemical composition and biological activities of <i>Artemisia quettensis</i> Podlech ethanolic extract Taylor & Francis Group 2017 GC-MS phytochemical composition Artemisia quettensis Podlech cytotoxicity 2017-04-20 07:34:42 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Phytochemical_composition_and_biological_activities_of_i_Artemisia_quettensis_i_Podlech_ethanolic_extract/4892495 <p>The present study aim to investigate the phytochemical composition, antibacterial, antioxidant and anticancer activities of the ethanolic extract from aerial parts of <i>Artemisia quettensis</i> Podlech. The aerial part of <i>A. quettensis</i> Podlech extract was used for Gas chromatography–mass spectrometry (GC-MS) analysis, antioxidant, antibacterial and <i>anticancer activities</i>. GC/MS analysis of extract from this plant showed 23 major components and the most dominant components were acetic acid, [4-(1-hydroxy-1-methylethyl) cyclohex-1-enyl] methyl ester (13.88%), trans-Phytol (10.06%) and 2,6-Dimethyl-2,6-octadiene-1,8-diol diacetate (6.8%). The extract had significant antibacterial and anticancer effects. The highest percentage of antioxidant activity was 78.46% at 2 mg/mL concentration of extract. Moreover, the highest antibacterial effects of extract were against to gram-positive bacteria and the IC<sub>50</sub> cell cytotoxicity value on HT29 cell line in 24 h, 48 h and 72 h were 31.54, 6.08 and 2.96 mg/mL, respectively. From this study, <i>A. quettensis</i> Podlech could be considered as a promising source for novel drug compounds.</p>