%0 Journal Article %A Simlandy, Amit Kumar %A Mukherjee, Santanu %D 2017 %T Catalytic Enantioselective Synthesis of 3,4-Unsubstituted Thiochromenes through Sulfa-Michael/Julia–Kocienski Olefination Cascade Reaction %U https://acs.figshare.com/articles/journal_contribution/Catalytic_Enantioselective_Synthesis_of_3_4-Unsubstituted_Thiochromenes_through_Sulfa-Michael_Julia_Kocienski_Olefination_Cascade_Reaction/4887227 %R 10.1021/acs.joc.7b00579.s001 %2 https://ndownloader.figshare.com/files/8208314 %K enantioselectivitie %K Olefination %K Sulfa-Michael %K Catalytic Enantioselective Synthesis %K thiochromene %K enantioselective %K olefination %K proceed %K 2- mercaptobenzaldehydes %K diphenylprolinol TMS ether %K vinyl PT-sulfones %K iminium %K Cascade %K Unsubstituted %K β- %K 2- substiuted 2 H %K sulfa-Michael %K cascade %K unsubstituted %K Thiochromene %K synthesis %X A highly enantioselective cascade sulfa-Michael/Julia–Kocienski olefination reaction between 2-mercaptobenzaldehydes and β-substituted vinyl PT-sulfones has been realized for the synthesis of 3,4-unsubstituted 2H-thiochromenes. This reaction, catalyzed by diphenylprolinol TMS ether, proceeds through an aromatic iminium intermediate and furnishes a wide range of 2-substiuted 2H-thiochromenes with excellent enantioselectivities (up to 99:1 er). %I ACS Publications