%0 Generic
%A Simlandy, Amit Kumar
%A Mukherjee, Santanu
%D 2017
%T Catalytic Enantioselective
Synthesis of 3,4-Unsubstituted
Thiochromenes through Sulfa-Michael/Julia–Kocienski Olefination
Cascade Reaction
%U https://acs.figshare.com/articles/dataset/Catalytic_Enantioselective_Synthesis_of_3_4-Unsubstituted_Thiochromenes_through_Sulfa-Michael_Julia_Kocienski_Olefination_Cascade_Reaction/4887224
%R 10.1021/acs.joc.7b00579.s002
%2 https://ndownloader.figshare.com/files/8208308
%K enantioselectivitie
%K Olefination
%K Sulfa-Michael
%K Catalytic Enantioselective Synthesis
%K thiochromene
%K enantioselective
%K olefination
%K proceed
%K 2- mercaptobenzaldehydes
%K diphenylprolinol TMS ether
%K vinyl PT-sulfones
%K iminium
%K Cascade
%K Unsubstituted
%K β-
%K 2- substiuted 2 H
%K sulfa-Michael
%K cascade
%K unsubstituted
%K Thiochromene
%K synthesis
%X A highly
enantioselective cascade sulfa-Michael/Julia–Kocienski
olefination reaction between 2-mercaptobenzaldehydes and β-substituted
vinyl PT-sulfones has been realized for the synthesis of 3,4-unsubstituted
2H-thiochromenes. This reaction, catalyzed by diphenylprolinol
TMS ether, proceeds through an aromatic iminium intermediate and furnishes
a wide range of 2-substiuted 2H-thiochromenes with
excellent enantioselectivities (up to 99:1 er).
%I ACS Publications