Catalytic Enantioselective Synthesis of 3,4-Unsubstituted Thiochromenes through Sulfa-Michael/Julia–Kocienski Olefination Cascade Reaction Amit Kumar Simlandy Santanu Mukherjee 10.1021/acs.joc.7b00579.s003 https://acs.figshare.com/articles/dataset/Catalytic_Enantioselective_Synthesis_of_3_4-Unsubstituted_Thiochromenes_through_Sulfa-Michael_Julia_Kocienski_Olefination_Cascade_Reaction/4887221 A highly enantioselective cascade sulfa-Michael/Julia–Kocienski olefination reaction between 2-mercaptobenzaldehydes and β-substituted vinyl PT-sulfones has been realized for the synthesis of 3,4-unsubstituted 2<i>H</i>-thiochromenes. This reaction, catalyzed by diphenylprolinol TMS ether, proceeds through an aromatic iminium intermediate and furnishes a wide range of 2-substiuted 2<i>H</i>-thiochromenes with excellent enantioselectivities (up to 99:1 er). 2017-04-07 00:00:00 enantioselectivitie Olefination Sulfa-Michael Catalytic Enantioselective Synthesis thiochromene enantioselective olefination proceed 2- mercaptobenzaldehydes diphenylprolinol TMS ether vinyl PT-sulfones iminium Cascade Unsubstituted β- 2- substiuted 2 H sulfa-Michael cascade unsubstituted Thiochromene synthesis