In Vivo Study of the Efficacy of the Essential Oil
of <i>Zanthoxylum bungeanum</i> Pericarp in Dextran Sulfate
Sodium-Induced Murine Experimental Colitis
Zecai Zhang
Peng Shen
Jiuxi Liu
Cong Gu
Xiaojie Lu
Yanxin Li
Yongguo Cao
Bo Liu
Yunhe Fu
Naisheng Zhang
10.1021/acs.jafc.7b01323.s001
https://acs.figshare.com/articles/journal_contribution/In_Vivo_Study_of_the_Efficacy_of_the_Essential_Oil_of_i_Zanthoxylum_bungeanum_i_Pericarp_in_Dextran_Sulfate_Sodium-Induced_Murine_Experimental_Colitis/4884806
The
purpose of this study was to investigate the protective effects
and mechanisms of the essential oil of <i>Zanthoxylum bungeanum</i> pericarp (ZBEO) on dextran sulfate sodium (DSS)-induced experimental
colitis in mice. ZBEO decreased DSS-induced body weight loss, the
disease activity index, colon length shortening, colonic pathological
damage, and myeloperoxidase activities. The production of pro-inflammatory
mediators was significantly alleviated by ZBEO. Further mechanistic
analysis showed that ZBEO inhibited inflammation by regulating NF-κB
and PPARγ pathways. ZBEO also inhibited NLRP3 activation in
colitis in mice. Furthermore, ZBEO contributed to the maintenance
of tight junction architecture by regulating the expression of zonula
occludens-1 during colitis. Surprisingly, treatment with ZBEO increased
levels of the commensal bacteria containing <i>Lactobacillus</i> and <i>Bifidobacteria</i> but reduced <i>Escherichia
coli</i> levels in the feces of mice. These results suggested
that supplementation with ZBEO might provide a new dietary strategy
for the prevention of ulcerative colitis.
2017-04-03 00:00:00
Zanthoxylum bungeanum Pericarp
Zanthoxylum bungeanum pericarp
disease activity index
zonula occludens
coliti
pro-inflammatory mediators
myeloperoxidase activities
Essential Oil
NLRP 3 activation
dextran sulfate sodium
Vivo Study
Escherichia coli levels
junction architecture
ZBEO
PPAR γ pathways
commensal bacteria
colon length
DSS-induced body weight loss
NF -κB
Dextran Sulfate Sodium-Induced Murine