10.1021/acs.orglett.7b00670.s002 Marko Jeran Marko Jeran Andrej Emanuel Cotman Andrej Emanuel Cotman Michel Stephan Michel Stephan Barbara Mohar Barbara Mohar Stereopure Functionalized Benzosultams via Ruthenium(II)-Catalyzed Dynamic Kinetic Resolution–Asymmetric Transfer Hydrogenation American Chemical Society 2017 Ru enantiopure ansa DKR Hydrogenation TsDPEN enantioselective ligand mix hydrogenation 4 Ph yn sulfonylamino ULTAM ee stereopure hydroxy-arylmethyl access DPEN -3-phenyl syn HCO isomer trans -4- Ruthenium transfer aminobenzyl Transfer conversion diastereo aryl ketones application II 4- hydroxy-benzo -δ- Dynamic sulfonylimino 10 000 Kinetic Stereopure Functionalized Benzosultams 2017-04-13 17:18:34 Dataset https://acs.figshare.com/articles/dataset/Stereopure_Functionalized_Benzosultams_via_Ruthenium_II_-Catalyzed_Dynamic_Kinetic_Resolution_Asymmetric_Transfer_Hydrogenation/4873568 A highly diastereo- and enantioselective Ru­(II)-catalyzed dynamic kinetic resolution–asymmetric transfer hydrogenation (DKR–ATH) of α-(<i>N</i>-sulfonylimino) and α-(<i>N</i>-sulfonylamino) aryl ketones to 4-hydroxy-benzo-δ- and 3-(α-hydroxy-arylmethyl)-benzo-γ-sultams is presented. By employing enantiopure <i>ansa</i>-Ru­[PipSO<sub>2</sub>DPEN­(CH<sub>2</sub>)<sub>4</sub>Ph] <b>cat. II</b> with S/C = 10 000 in a HCO<sub>2</sub>H/Et<sub>3</sub>N binary mix, up to >99.9% ee and dr >99:1 are obtained with 100% conversion under mild conditions. Application to access the stereopure “structurally simplified TsDPEN” <i>N</i>,<i>N</i>-ligand s<i>yn</i>-3-(α-aminobenzyl)-benzo-γ-sultam (“<i>syn</i>-ULTAM”) and its structural isomer <i>trans</i>-4-amino-3-phenyl-benzo-δ-sultam (<i>trans</i>-<b>4</b>) is demonstrated.