10.6084/m9.figshare.4814911.v1
Hellmuth C.
Hellmuth
C.
Uhl O.
Uhl
O.
Standl M.
Standl
M.
Demmelmair H.
Demmelmair
H.
Heinrich J.
Heinrich
J.
Koletzko B.
Koletzko
B.
Thiering E.
Thiering
E.
Supplementary Material for: Cord Blood Metabolome Is Highly Associated with Birth Weight, but Less Predictive for Later Weight Development
Karger Publishers
2017
Cord blood
Metabolomics
Early programming
Childhood obesity
2017-04-04 13:31:38
Journal contribution
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Cord_Blood_Metabolome_Is_Highly_Associated_with_Birth_Weight_but_Less_Predictive_for_Later_Weight_Development/4814911
<p><b><i>Background/Aims: </i></b>Fetal metabolism may be changed by the
exposure to maternal factors, and the route to obesity may already set
in utero. Cord blood metabolites might predict growth patterns and later
obesity. We aimed to characterize associations of cord blood with birth
weight, postnatal weight gain, and BMI in adolescence. <b><i>Methods: </i></b>Over
700 cord blood samples were collected from infants participating in the
German birth cohort study LISAplus. Glycerophospholipid fatty acids
(GPL-FA), polar lipids, non-esterified fatty acids (NEFA), and amino
acids were analyzed with a targeted, liquid chromatography-tandem mass
spectrometry based metabolomics platform. Cord blood metabolites were
related to growth factors by linear regression models adjusted for
confounding variables. <b><i>Results: </i></b>Cord blood metabolites
were highly associated with birth weight. Lysophosphatidylcholines
C16:1, C18:1, C20:3, C18:2, C20:4, C14:0, C16:0, C18:3, GPL-FA C20:3n-9,
and GPL-FA C22:5n-6 were positively related to birth weight, while
higher cord blood concentrations of NEFA C22:6, NEFA C20:5, GPL-FA
C18:3n-3, and PCe C38:0 were associated with lower birth weight.
Postnatal weight gain and BMI z-scores in adolescents were not
significantly associated with cord blood metabolites after adjustment
for multiple testing. <b><i>Conclusion: </i></b>Potential long-term
programming effects of the intrauterine environment and metabolism on
later health cannot be predicted with profiling of the cord blood
metabolome.</p>