TY - DATA T1 - A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity PY - 2017/03/28 AU - S. N. Suresh AU - Aravinda K. Chavalmane AU - Vidyadhara DJ AU - Haorei Yarreiphang AU - Shashank Rai AU - Abhik Paul AU - James P. Clement AU - Phalguni Anand Alladi AU - Ravi Manjithaya UR - https://tandf.figshare.com/articles/journal_contribution/A_novel_autophagy_modulator_6-Bio_ameliorates_SNCA_-synuclein_toxicity/4793893 DO - 10.6084/m9.figshare.4793893.v1 L4 - https://ndownloader.figshare.com/files/7881640 KW - 6-Bio KW - autolysosomes KW - autophagy KW - high-throughput screening KW - MPTP KW - neurodegeneration, SNCA KW - TH N2 - Parkinson disease (PD) is a life-threatening neurodegenerative movement disorder with unmet therapeutic intervention. We have identified a small molecule autophagy modulator, 6-Bio that shows clearance of toxic SNCA/α-synuclein (a protein implicated in synucleopathies) aggregates in yeast and mammalian cell lines. 6-Bio induces autophagy and dramatically enhances autolysosome formation resulting in SNCA degradation. Importantly, neuroprotective function of 6-Bio as envisaged by immunohistology and behavior analyses in a preclinical model of PD where it induces autophagy in dopaminergic (DAergic) neurons of mice midbrain to clear toxic protein aggregates suggesting that it could be a potential therapeutic candidate for protein conformational disorders. ER -