10.6084/m9.figshare.4793356.v1
Anirban Ash
Anirban
Ash
Yogesh P. Bharitkar
Yogesh
P. Bharitkar
Sanatan Murmu
Sanatan
Murmu
Abhijit Hazra
Abhijit
Hazra
V. Ravichandiran
V.
Ravichandiran
Pradip Kumar Kar
Pradip
Kumar Kar
Nirup Bikash Mondal
Nirup
Bikash Mondal
Ultrastructural changes in <i>Raillietina</i> (Platyhelminthes: cestoda), exposed to sulfonoquinovosyldiacylglyceride (SQDG), isolated from Neem (<i>Azadirachta indica</i>)
Taylor & Francis Group
2017
Anthelminthic
Azadirachta indica
sulfonoquinovosyldiacylglyceride
Raillietina
anticestodal efficacy
SEM
2017-03-28 08:55:52
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Ultrastructural_changes_in_i_Raillietina_i_Platyhelminthes_cestoda_exposed_to_sulfonoquinovosyldiacylglyceride_SQDG_isolated_from_Neem_i_Azadirachta_indica_i_/4793356
<p>Neem (<i>Azadirachta indica</i>), has been known to be a curative for various ailments and diseases in the traditional Indian medicinal system from times immemorial. A glycolipid sulfonoquinovosyldiacylglyceride (SQDG) isolated from the leaves of neem has been found to be a proactive antibacterial and antiviral agent in previous studies. The current communication pertains to the anthelmintic activity of SQDG <i>in vitro</i> against a model cestode <i>Raillietina</i> spp. The results of efficacy tests showed a paralysis time of 1.0 ± 0.1 and 0.7 ± 0.01 h, whereas death time of 1.6 ± 0.3 and 0.9 ± 0.02 h, following treatments with dosages of 0.5 and 1.0 mg/mL, respectively. The scanning electron microscopic studies showed significant and unique changes in the ultrastructure of the worms with prominent breakages and furrows on the surface.</p>