10.6084/m9.figshare.4793356.v1 Anirban Ash Anirban Ash Yogesh P. Bharitkar Yogesh P. Bharitkar Sanatan Murmu Sanatan Murmu Abhijit Hazra Abhijit Hazra V. Ravichandiran V. Ravichandiran Pradip Kumar Kar Pradip Kumar Kar Nirup Bikash Mondal Nirup Bikash Mondal Ultrastructural changes in <i>Raillietina</i> (Platyhelminthes: cestoda), exposed to sulfonoquinovosyldiacylglyceride (SQDG), isolated from Neem (<i>Azadirachta indica</i>) Taylor & Francis Group 2017 Anthelminthic Azadirachta indica sulfonoquinovosyldiacylglyceride Raillietina anticestodal efficacy SEM 2017-03-28 08:55:52 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Ultrastructural_changes_in_i_Raillietina_i_Platyhelminthes_cestoda_exposed_to_sulfonoquinovosyldiacylglyceride_SQDG_isolated_from_Neem_i_Azadirachta_indica_i_/4793356 <p>Neem (<i>Azadirachta indica</i>), has been known to be a curative for various ailments and diseases in the traditional Indian medicinal system from times immemorial. A glycolipid sulfonoquinovosyldiacylglyceride (SQDG) isolated from the leaves of neem has been found to be a proactive antibacterial and antiviral agent in previous studies. The current communication pertains to the anthelmintic activity of SQDG <i>in vitro</i> against a model cestode <i>Raillietina</i> spp. The results of efficacy tests showed a paralysis time of 1.0 ± 0.1 and 0.7 ± 0.01 h, whereas death time of 1.6 ± 0.3 and 0.9 ± 0.02 h, following treatments with dosages of 0.5 and 1.0 mg/mL, respectively. The scanning electron microscopic studies showed significant and unique changes in the ultrastructure of the worms with prominent breakages and furrows on the surface.</p>