Quaternary Carbon Center Forming Formal [3 + 3] Cycloaddition
Reaction via Bifunctional Catalysis: Asymmetric Synthesis of Spirocyclohexene
Pyrazolones
Jin-Yu Liu
Jing Zhao
Jia-Lu Zhang
Peng-Fei Xu
10.1021/acs.orglett.7b00610.s001
https://acs.figshare.com/articles/journal_contribution/Quaternary_Carbon_Center_Forming_Formal_3_3_Cycloaddition_Reaction_via_Bifunctional_Catalysis_Asymmetric_Synthesis_of_Spirocyclohexene_Pyrazolones/4787620
A variety of spirocyclohexene pyrazolones
were synthesized in good
yields with excellent stereoselectivities through an asymmetric, intermolecular,
quaternary carbon center forming [3 + 3] cycloaddition reaction catalyzed
by a bifunctional catalyst. The vinylogous pyrazolones used as binucleophilic
synthons in this reaction exhibited superior ability for constructing
pyrazolone related spirocyclic scaffolds.
2017-03-24 19:06:14
vinylogous pyrazolones
spirocyclic scaffolds
Spirocyclohexene Pyrazolones
quaternary carbon center
Asymmetric Synthesis
spirocyclohexene pyrazolones
binucleophilic synthons
Bifunctional Catalysis
bifunctional catalyst