%0 Journal Article %A Zhao, Ren %A Lu, Wenjun %D 2017 %T Palladium-Catalyzed β‑Mesylation of Simple Amide via Primary sp3 C–H Activation %U https://acs.figshare.com/articles/journal_contribution/Palladium-Catalyzed_Mesylation_of_Simple_Amide_via_Primary_sp_sup_3_sup_C_H_Activation/4776553 %R 10.1021/acs.orglett.7b00536.s001 %2 https://ndownloader.figshare.com/files/7842535 %K intramolecular S N 2 processes %K β- fluoroamides %K methanesulfonic anhydride %K CH %K β- lactams %K OH %K cyclic alkanes %K electron-deficient benzyl compounds %K Simple Amide %K sp %K amide substrates %K β- mesylation %K Ms 2 O %K β- mesylated amide products %X A β-mesylation of primary sp3 C–H bonds from simple amides with methanesulfonic anhydride (Ms2O) has been established successfully at 80 °C in a Pd­(OAc)2 (catalyst)/K2S2O8 (oxidant)/CF3CH2OH (solvent) system. These amide substrates involve N-monosubstituted linear, branch, or cyclic alkanes, and electron-deficient benzyl compounds. The β-mesylated amide products can be converted easily to β-fluoroamides or β-lactams through inter- or intramolecular SN2 processes. %I ACS Publications