10.1371/journal.pone.0174196.s001
Kyosuke Uno
Kyosuke
Uno
Toh Miyazaki
Toh
Miyazaki
Kengo Sodeyama
Kengo
Sodeyama
Yoshiaki Miyamoto
Yoshiaki
Miyamoto
Atsumi Nitta
Atsumi
Nitta
The relationship of drd1a gene to <i>Shati/Nat8L</i> expression.
Public Library of Science
2017
mouse NAc slices
METH activates CREB binding
PC 12 cells
mouse brain slices
mouse NAc
dopamine receptor signals
group II mGluRs
SCH
mouse nucleus accumbens
dopamine D 2 receptor antagonist sulpiride
mRNA
expression
CREB activity
dopamine D 1 receptor
METH-induced CREB pathway
dopamine D 1 receptor agonist SKF 38393
Shati
mouse NAc attenuated METH-induced hyperlocomotion
2017-03-20 18:04:28
Figure
https://plos.figshare.com/articles/figure/Methamphetamine_induces_Shati_Nat8L_expression_in_the_mouse_nucleus_accumbens_via_CREB-_and_dopamine_D1_receptor-dependent_mechanism/4767595
<p>The Figure indicates that the relationship between Shati/Nat8L expression and METH effect on brain slice experiments. **<i>p</i><0.01 <i>vs</i>. aCSF. (Newman–Keuls post hoc test). (B) Dopamine D1 or D2 receptor antagonist (D1: SCH23390 10uM, D2: sulpiride 10uM) was pretreated before METH (1mM) stimulation for qPCR of Shati/Nat8L mRNA. **<i>p</i><0.01 and ***<i>p</i><0.001 <i>vs</i>., aCSF## <i>p</i><0.01 <i>vs</i>.METH. (Newman–Keuls post hoc test). (C) PC12 cells transfected with drd1a or drd2 were taken for qPCR 48 after the transfection * <i>p</i><0.05 vs pcDNA (Newman–Keuls post hoc test). Error bars represent the S.E. M</p> <p>(TIF)</p>