10.1371/journal.pone.0174196.s001 Kyosuke Uno Kyosuke Uno Toh Miyazaki Toh Miyazaki Kengo Sodeyama Kengo Sodeyama Yoshiaki Miyamoto Yoshiaki Miyamoto Atsumi Nitta Atsumi Nitta The relationship of drd1a gene to <i>Shati/Nat8L</i> expression. Public Library of Science 2017 mouse NAc slices METH activates CREB binding PC 12 cells mouse brain slices mouse NAc dopamine receptor signals group II mGluRs SCH mouse nucleus accumbens dopamine D 2 receptor antagonist sulpiride mRNA expression CREB activity dopamine D 1 receptor METH-induced CREB pathway dopamine D 1 receptor agonist SKF 38393 Shati mouse NAc attenuated METH-induced hyperlocomotion 2017-03-20 18:04:28 Figure https://plos.figshare.com/articles/figure/Methamphetamine_induces_Shati_Nat8L_expression_in_the_mouse_nucleus_accumbens_via_CREB-_and_dopamine_D1_receptor-dependent_mechanism/4767595 <p>The Figure indicates that the relationship between Shati/Nat8L expression and METH effect on brain slice experiments. **<i>p</i><0.01 <i>vs</i>. aCSF. (Newman–Keuls post hoc test). (B) Dopamine D1 or D2 receptor antagonist (D1: SCH23390 10uM, D2: sulpiride 10uM) was pretreated before METH (1mM) stimulation for qPCR of Shati/Nat8L mRNA. **<i>p</i><0.01 and ***<i>p</i><0.001 <i>vs</i>., aCSF## <i>p</i><0.01 <i>vs</i>.METH. (Newman–Keuls post hoc test). (C) PC12 cells transfected with drd1a or drd2 were taken for qPCR 48 after the transfection * <i>p</i><0.05 vs pcDNA (Newman–Keuls post hoc test). Error bars represent the S.E. M</p> <p>(TIF)</p>