10.6084/m9.figshare.4763737.v1 Xiao Yi Xiao Yi Jing Chen Jing Chen Xiuling Xu Xiuling Xu Yongmin Ma Yongmin Ma Solvent and substituent effects on the conversion of 4-methoxypyridines to N-methyl-4-pyridones Taylor & Francis Group 2017 Pyridone rearrangement solvent effect substituent effect 2017-03-17 15:21:06 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Solvent_and_substituent_effects_on_the_conversion_of_4-methoxypyridines_to_N-methyl-4-pyridones/4763737 <p>In the reaction of 4-methoxypyridine derivatives with alkyl iodides in the presence or absence of solvent, not only the pyridinium ions but also the related 1-methylpyridones are produced. The presence of solvent favors the formation of the 1-methylpyridone. Electron withdrawing groups on the pyridine ring also favor this conversion. A possible mechanism is presented.</p>