10.6084/m9.figshare.4763737.v1
Xiao Yi
Xiao
Yi
Jing Chen
Jing
Chen
Xiuling Xu
Xiuling
Xu
Yongmin Ma
Yongmin
Ma
Solvent and substituent effects on the conversion of 4-methoxypyridines to N-methyl-4-pyridones
Taylor & Francis Group
2017
Pyridone
rearrangement
solvent effect
substituent effect
2017-03-17 15:21:06
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Solvent_and_substituent_effects_on_the_conversion_of_4-methoxypyridines_to_N-methyl-4-pyridones/4763737
<p>In the reaction of 4-methoxypyridine derivatives with alkyl iodides in the presence or absence of solvent, not only the pyridinium ions but also the related 1-methylpyridones are produced. The presence of solvent favors the formation of the 1-methylpyridone. Electron withdrawing groups on the pyridine ring also favor this conversion. A possible mechanism is presented.</p>