Supplementary Material for: Serial Ultrasonographic Examination of the Fetal Thymus in the Prediction of Early Neonatal Sepsis in Preterm Premature Rupture of Membranes
Cetin O.
Dokurel Cetin I.
Uludag S.
Sen C.
Verit F.F.
Guralp O.
10.6084/m9.figshare.4750897.v1
https://karger.figshare.com/articles/journal_contribution/Supplementary_Material_for_Serial_Ultrasonographic_Examination_of_the_Fetal_Thymus_in_the_Prediction_of_Early_Neonatal_Sepsis_in_Preterm_Premature_Rupture_of_Membranes/4750897
<p><b><i>Background/Aims:</i></b> To evaluate the diagnostic accuracy of
fetal thymus transverse diameter (FTTD) in predicting fetal infection
in preterm premature rupture of membranes (PPROM) and compare its
accuracy with cord blood tumor necrosis factor-α (TNF-α) and
interleukin-6 (IL-6). <b><i>Methods:</i></b> Forty consecutive pregnancies complicated with PPROM between 26<sup>1/7</sup> and 36<sup>6/7</sup>
gestational weeks were evaluated prospectively. Serial fetal
ultrasonography follow-ups with 3-day intervals were performed beginning
on the admission day. The FTTD was recorded on every ultrasonographic
examination. Cord blood TNF-α and IL-6 values were measured after
delivery. <b><i>Results:</i></b> FTTD was decreased below 5% according
to nomograms compared to the initial measurement in 45% of all PPROM
cases. Decreased FTTD had a sensitivity of 100%, specificity of 73%,
positive predictive value of 55%, and negative predictive value of 100%
in predicting early neonatal sepsis. Cord blood TNF-α had a sensitivity
of 80% and specificity of 90%, whereas IL-6 had a sensitivity of 90% and
specificity of 63.3% in predicting early neonatal sepsis. <b><i>Conclusions:</i></b>
Assessment of the decrease in FTTD by serial ultrasonographic
examinations is a promising ‘prenatal' method for the early detection of
early neonatal sepsis.</p>
2017-03-14 12:17:08
Preterm premature rupture of membranes
Fetal thymus transverse diameter
Early neonatal sepsis
Interleukin-6
Tumor necrosis factor-α