10.1371/journal.pone.0172179.g003 Laura J. Sherrard Laura J. Sherrard Anna S. Tai Anna S. Tai Bryan A. Wee Bryan A. Wee Kay A. Ramsay Kay A. Ramsay Timothy J. Kidd Timothy J. Kidd Nouri L. Ben Zakour Nouri L. Ben Zakour David M. Whiley David M. Whiley Scott A. Beatson Scott A. Beatson Scott C. Bell Scott C. Bell Ternary plot of amino acid sequence variation in genes associated with antibiotic resistance and hypermutation. Public Library of Science 2017 multi-drug efflux pumps genome sequencing M 3L resistance mutation Pseudomonas aeruginosa strain sub-type core genome SNPs antibiotic treatment Multiple clonal lineages antibiotic resistance genes Pseudomonas aeruginosa AUST -02 strain sub-type M 3L population antibiotic resistance M 3L 2017-03-08 18:33:10 Figure https://plos.figshare.com/articles/figure/Ternary_plot_of_amino_acid_sequence_variation_in_genes_associated_with_antibiotic_resistance_and_hypermutation_/4734427 <p>M3L7 isolates were cultured from sputum samples during intravenous treatment of an acute pulmonary exacerbation (Days 1, 7, 14 and 23) and at outpatient follow-up 8 weeks later. Protein sequences (compared to PAO1) were grouped according to the resistance they confer or to their biological function and three colors are used to filter the proteins. The complete plot with the full set of chromosomally encoded proteins investigated, genetic mutations identified and PROVEAN scores are available in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0172179#pone.0172179.s005" target="_blank">S1 Table</a>. *Premature stop codon; <sup>+</sup>FtsI (G63C) identified in all other M3L7 isolates (Group A and C); <sup>^</sup>Additional frame-shift mutation detected in AUS964.</p>