F., Bai Y., Lu K., Wu Q., Chen L., Ding M., Ge Z., Weng Supplementary Material for: Protecting Effects of Gonadotropin-Releasing Hormone Agonist on Chemotherapy-Induced Ovarian Damage in Premenopausal Breast Cancer Patients: A Systematic Review and Meta-Analysis <p><b><i>Objective:</i></b> There is no universal consensus on whether gonadotropin-releasing hormone (GnRH) agonist could protect chemotherapy-induced ovarian damage in premenopausal breast cancer patients. This meta-analysis was conducted to estimate the protective effects of GnRH agonist on premenopausal breast cancer patients in details. <b><i>Methods:</i></b> PubMed, Cochrane Library, Embase, CNKI and the Chinese Wangfang Database, conference proceedings and clinical trials were searched to find studies reported since 2000. Heterogeneity for the eligible data was assessed and a pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. <b><i>Results:</i></b> Resumption of menses rate was improved in the GnRH agonist and chemotherapy-combination groups versus chemotherapy-alone groups (OR = 1.36, 95% CI: 1.19-1.56). Furthermore, the results indicated that spontaneous pregnancy rate was improved in the experimental groups versus the controls (OR = 1.90, 95% CI: 1.06-3.41). In addition, no publication bias was found using a Begg's funnel plot. <b><i>Conclusion:</i></b> The results of the current meta-analysis indicate that a GnRH agonist could improve resumption of menses rate and pregnancy rate for premenopausal breast cancer patients. However, more evaluation may be considered to prove this theory.</p> Premenopausal breast cancer;GnRH agonist;Resumption of menses rate;Meta-analysis 2017-03-07
    https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Protecting_Effects_of_Gonadotropin-Releasing_Hormone_Agonist_on_Chemotherapy-Induced_Ovarian_Damage_in_Premenopausal_Breast_Cancer_Patients_A_Systematic_Review_and_Meta-Analysis/4729867
10.6084/m9.figshare.4729867.v1