Supplementary Material for: Reactions of Buckwheat-Hypersensitive Patients during Oral Food Challenge Are Rare, but Often Anaphylactic
Yanagida N.
Sato S.
Takahashi K.
Nagakura K.
Ogura K.
Asaumi T.
Ebisawa M.
10.6084/m9.figshare.4729732.v1
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Reactions_of_Buckwheat-Hypersensitive_Patients_during_Oral_Food_Challenge_Are_Rare_but_Often_Anaphylactic/4729732
<p><b><i>Background:</i></b> Buckwheat (BW) is a common cause of
life-threatening allergy in Asia. Few have examined oral food challenges
(OFCs) using BW. We here describe the OFC outcomes for the diagnosis or
confirmation of tolerance acquisition and clarify risk factors for
positive OFCs. <b><i>Methods:</i></b> Between July 2005 and March 2014,
we retrospectively reviewed data from children who underwent OFCs using
3,072 mg of BW protein at Sagamihara National Hospital. Children were
suspected of having BW allergy because of positive results for
BW-specific IgE or because they had been previously diagnosed with BW
allergy owing to immediate reactions to BW. <b><i>Results:</i></b> Of
476 such patients, we analyzed 419 aged 1-17 years (median age 6.7
years). Forty-four (10.5%) reacted to the BW OFC and 24 (54.5%)
experienced anaphylaxis. Among patients with suspected BW allergies (<i>n</i> = 369), 30 (8.1%) reacted to OFC. However, among patients with definitive BW allergies (<i>n</i>
= 50) who underwent OFCs a median of 7.0 years after their last
immediate reaction, 14 (28.0%) reacted to OFC. Among 12 patients with
past anaphylactic reactions to BW, 8 exhibited tolerance to BW. A
history of immediate reaction to BW and high BW-specific IgE levels were
significant risk factors for a positive OFC. <b><i>Conclusions:</i></b>
BW allergies are rare among children suspected of having BW allergies
due to positivity for BW-specific IgE. Most children with definitive BW
allergies can tolerate BW, even after anaphylactic reactions.
Nevertheless, careful observation is needed when performing BW OFCs,
considering the high incidence of anaphylactic reactions.</p>
2017-03-07 12:19:05
Buckwheat
Food allergy
Food hypersensitivity
IgE
Oral food challenge