MOESM2 of Molecular mechanism of G1 arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells
Yan-Fang Tao
Na-Na Wang
Li-Xiao Xu
Zhi-Heng Li
Xiao-Lu Li
Yun-Yun Xu
Fang Fang
Mei Li
Guang-Hui Qian
Yan-Hong Li
Yi-Ping Li
Yi Wu
Jun-Li Ren
Wei-Wei Du
Jun Lu
Xing Feng
Jian Wang
Wei-Qi He
Shao-Yan Hu
Jian Pan
10.6084/m9.figshare.c.3710392_D2.v1
https://springernature.figshare.com/articles/figure/MOESM2_of_Molecular_mechanism_of_G1_arrest_and_cellular_senescence_induced_by_LEE011_a_novel_CDK4_CDK6_inhibitor_in_leukemia_cells/4728886
Additional file 2. Cell cycle analysis of acute leukemia cells treated with LEE011. Cell cycle analysis showed the cells treated with LEE011 2 and 5 μM for 48 hours, results showed in these acute leukemia cells, LEE011 induce the cell cycle G1 arrest very significantly.G1 phase cells in MV4-11 treated with 5 μM group was 83.82±2.81% vs. DMSO group 44.66±1.90%, P<0.01. G1 phase cells in SHI-1 treated with 5 μM group was 87.39±2.80% vs. DMSO group 45.25±4.61%, P<0.01. G1 phase cells in THP-1 treated with 5 μM group was 50.51±8.17% vs. DMSO group 45.64±6.46 %, P=0.466. G1 phase cells in U937 treated with 5 μM group was 89.99±3.54% vs. DMSO group 54.26±2.92 %, P<0.01. ** P < 0.01.
2017-03-06 05:00:00
LEE011
Leukemia
CDK4/6
Cellular senescence
Arraystar Human LncRNA array