Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX John H. Hutchinson Martin W. Rowbottom David Lonergan Janice Darlington Pat Prodanovich Christopher D. King Jilly F. Evans Gretchen Bain 10.1021/acsmedchemlett.7b00014.s001 https://acs.figshare.com/articles/journal_contribution/Small_Molecule_Lysyl_Oxidase-like_2_LOXL2_Inhibitors_The_Identification_of_an_Inhibitor_Selective_for_LOXL2_over_LOX/4728520 Two series of novel LOXL2 enzyme inhibitors are described: benzylamines substituted with electron withdrawing groups at the <i>para</i>-position and 2-substituted pyridine-4-ylmethanamines. The most potent compound, (2-chloropyridin-4-yl)­methanamine <b>20</b> (hLOXL2 IC<sub>50</sub> = 126 nM), was shown to be selective for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B, and SSAO). Compound <b>20</b> is the first published small molecule inhibitor selective for LOXL2 over LOX. 2017-03-01 00:00:00 MAO-A hLOXL 2 IC 50 novel LOXL 2 enzyme inhibitors Small Molecule Lysyl Oxidase-like 2 Inhibitor MAO-B LOXL 2 SSAO