%0 Generic %A De, Pinaki Bhusan %A Pradhan, Sourav %A Punniyamurthy, Tharmalingam %D 2017 %T Stereoselective Copper-Catalyzed Cross-Coupling of Aziridines with Benzimidazoles via Nucleophilic Ring Opening and C(sp2)–H Functionalization %U https://acs.figshare.com/articles/dataset/Stereoselective_Copper-Catalyzed_Cross-Coupling_of_Aziridines_with_Benzimidazoles_via_Nucleophilic_Ring_Opening_and_C_sp_sup_2_sup_H_Functionalization/4725820 %R 10.1021/acs.joc.7b00265.s001 %2 https://ndownloader.figshare.com/files/7715596 %K 2- arylaziridines %K ee %K stereoinvertivebly cross-coupled %K Functionalization %K benzimidazole %K Optically %K dehydrogenative cross-coupling %K puritie %K regiospecific ring opening %K Stereoselective Copper-Catalyzed Cross-Coupling %K enantiomeric %K Cu %K dihydroimidazobenzimidazole %K benzoimidazolylethylamine derivatives %K PCy 3 ligand %K copper-catalyzed cross-coupling %K Aziridine %K alkyl %K Nucleophilic Ring %K Benzimidazole %K bond %X A copper-catalyzed cross-coupling of 2-alkyl-/2-arylaziridines with benzimidazoles is reported. The reactions involve a regiospecific ring opening of aziridines with benzimidazoles to give benzoimidazolylethylamine derivatives that lead to dehydrogenative cross-coupling between C­(sp2)-H and N–H bonds to produce dihydroimidazobenzimidazoles. Optically active 2-arylaziridines can be stereoinvertivebly cross-coupled with high enantiomeric purities (77–97% ee). These aerobic catalytic systems comprise an inexpensive Cu­(II) salt and PCy3 ligand at moderate temperature. %I ACS Publications