Pharmacological inhibition of Nox2 oxidase activity.
Ross Vlahos
John Stambas
Steven Bozinovski
Brad R. S. Broughton
Grant R. Drummond
Stavros Selemidis
10.1371/journal.ppat.1001271.g009
https://plos.figshare.com/articles/figure/Pharmacological_inhibition_of_Nox2_oxidase_activity_/471689
<p>Effect of apocynin (Apo, 2.5 mg/kg) treatment on (A) BALF cellularity, (B) BALF inflammatory cell superoxide production and (C) viral titer in H3N2 (X-31) influenza A virus-infected WT mice 3 days post infection. Also, effect of apocynin treatment on (D) BALF cellularity and (E) BALF inflammatory cell superoxide production in H1N1 (PR8) influenza A virus-infected WT mice 3 days post infection. Data are shown as mean ± SD for 6–8 mice per treatment group. *<i>P</i><0.05 vs WT vehicle (Control)-treated mice (ANOVA followed by Dunnett's <i>post hoc</i> test for (A and D) but Students' unpaired <i>t</i> test used for B, C and E).</p>
2013-02-20 20:50:00
inhibition
nox2
oxidase