Central immunological position of the human histo (blood) group O(H).
Peter Arend
10.6084/m9.figshare.4714618.v66
https://figshare.com/articles/journal_contribution/Central_immunological_position_of_the_human_histo_blood_group_O_H_/4714618
<p><br></p><p>Prokaryotic "blood group A/B-like"
antigenic structures apparently induce basically cross-reactive anti-A/B
immunoglobulins, which due to clonal selection neither arise in blood group
A nor in B individuals but occur exclusively in blood group O. While bacterial endotoxins non-specifically stimulate the formation of all
immunoglobulins, most likely involving the anti-A/B isoagglutinins, a definite,
adaptive immunological induction of these agglutinins appears to be restricted
to blood group O(H) individuals. In the non-O blood groups, anti-A/B reactivity
is exerted by a primarily blood group-independent, polyreactive and thymus-independent non-immune IgM molecule that has undergone
the phenotype-specific, glycosidic accommodation of plasma proteins, which
reduces or excludes anti-self reactivity, however, necessarily involves impairment
of immunity. While blood group A phenotype development thus is associated with impairment of both adaptive and
innate immunity, it promotes
susceptibility to malaria infection via these intrinsic enzyme functions, initiating a self-destructive glycosidic, phenotypic accommodation of a "wrong eukaryote". In fact, blood group A phenotype-specific
GalNAc transferase(s) and serine/threonine kinases, which are imported from <i>Plasmodium falciparum</i> into the red cell
membrane, might provide the metabolic condition for malaria rosette formation, assumingly based on heterologous <i>O</i>-glycosylation of
serine/threonine residues. Thus, lack of blood group A/B-specific phenotype glycosylations might explain the superior adaptive and innate immunity of the human blood group O(H) and its obvious protection from severe malaria infection,
which currently is discussed to
contribute to the global distribution of ABO blood groups in the human
population. </p><p></p>
2017-04-28 21:59:56
Aberrant expression
Cancer