10.6084/m9.figshare.4702426.v1
Anor C.J.
Anor
C.J.
O'Connor S.
O'Connor
S.
Saund A.
Saund
A.
Tang-Wai D.F.
Tang-Wai
D.F.
Keren R.
Keren
R.
Tartaglia M.C.
Tartaglia
M.C.
Supplementary Material for: Neuropsychiatric Symptoms in Alzheimer Disease, Vascular Dementia, and Mixed Dementia
Karger Publishers
2017
Alzheimer disease
Vascular dementia
Neuropsychiatric symptoms
Neuroimaging
2017-02-28 11:59:50
Dataset
https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Neuropsychiatric_Symptoms_in_Alzheimer_Disease_Vascular_Dementia_and_Mixed_Dementia/4702426
<p><b><i>Background/Aims:</i></b> Neuropsychiatric symptoms (NPS) are
common in Alzheimer disease (AD) and vascular dementia (VaD), and are
distressful to patients and caregivers. NPS are likely related to the
underlying pathology. Previous studies suggest that frontal lobe lesions
and vascular changes such as white matter hyperintensities (WMH) have a
significant association with specific NPS. The current study aimed to
compare NPS in patients with AD, VaD, and mixed AD/VaD, and to evaluate
the differences in the prevalence of NPS in relation to frontal WMH
volume. <b><i>Methods:</i></b> In total, 180 patients with NPS and MRI
data (92 probable AD, 51%; 34 probable VaD, 19%; and 54 probable mixed
AD/VaD, 30%) were included in the study. Regression analyses were
performed to determine the relationships between NPS prevalence and
diagnosis, and between NPS and frontal WMH. <b><i>Results:</i></b> VaD patients had significantly more agitation (<i>p</i> < 0.05; 40 vs. 14%) and sleep disturbances (<i>p</i> < 0.05; 57 vs. 32%) than AD patients, and significantly more depression (<i>p</i> < 0.05; 48 vs. 20%) and aberrant motor behaviors (<i>p</i>
< 0.05; 31 vs. 13%) than mixed AD/VaD patients. AD patients with
delusions had significantly greater right frontal WMH volumes than those
without (<i>p</i> < 0.05; delusions 1/0 = 314.8/112.6 mm<sup>3</sup>). <b><i>Conclusion:</i></b>
Differences in NPS prevalence are likely related to the underlying
pathology and warrant further study as they have implications for
treatment.</p>