Li, Guo-Tai Li, Zhi-Ke Gu, Qing You, Shu-Li Asymmetric Synthesis of 4‑Aryl-3,4-dihydrocoumarins by <i>N</i>‑Heterocyclic Carbene Catalyzed Annulation of Phenols with Enals The highly enantioselective synthesis of 4-aryl-3,4-dihydrocoumarins was realized through direct annulation of phenols with enals catalyzed by dihydroisoquinoline-type NHC (DHIQ-NHC), an <i>N</i>-heterocyclic carbene derived from l-phenylalanine. The catalytic reaction proceeds with a wide scope of electron-rich phenols and enals providing structurally diverse 4-aryl-3,4-dihydrocoumarins in good to excellent yields and enantioselectivity. This method was useful in the synthesis of natural products and biologically relevant compounds from readily available starting materials. enantioselectivity;Annulation;enal;Phenol;annulation;4-;Carbene;scope;enantioselective synthesis;method;reaction proceeds;Asymmetric Synthesis;heterocyclic carbene;material;Heterocyclic;yield;Aryl;compound;Catalyzed;dihydroisoquinoline-type NHC;DHIQ-NHC;electron-rich phenols;Enal;l-phenylalanine;aryl 2017-02-23
    https://acs.figshare.com/articles/dataset/Asymmetric_Synthesis_of_4_Aryl-3_4-dihydrocoumarins_by_i_N_i_Heterocyclic_Carbene_Catalyzed_Annulation_of_Phenols_with_Enals/4688527
10.1021/acs.orglett.7b00088.s002