10.1021/acs.orglett.7b00088.s002 Guo-Tai Li Guo-Tai Li Zhi-Ke Li Zhi-Ke Li Qing Gu Qing Gu Shu-Li You Shu-Li You Asymmetric Synthesis of 4‑Aryl-3,4-dihydrocoumarins by <i>N</i>‑Heterocyclic Carbene Catalyzed Annulation of Phenols with Enals American Chemical Society 2017 enantioselectivity Annulation enal Phenol annulation 4- Carbene scope enantioselective synthesis method reaction proceeds Asymmetric Synthesis heterocyclic carbene material Heterocyclic yield Aryl compound Catalyzed dihydroisoquinoline-type NHC DHIQ-NHC electron-rich phenols Enal l-phenylalanine aryl 2017-02-23 22:03:31 Dataset https://acs.figshare.com/articles/dataset/Asymmetric_Synthesis_of_4_Aryl-3_4-dihydrocoumarins_by_i_N_i_Heterocyclic_Carbene_Catalyzed_Annulation_of_Phenols_with_Enals/4688527 The highly enantioselective synthesis of 4-aryl-3,4-dihydrocoumarins was realized through direct annulation of phenols with enals catalyzed by dihydroisoquinoline-type NHC (DHIQ-NHC), an <i>N</i>-heterocyclic carbene derived from l-phenylalanine. The catalytic reaction proceeds with a wide scope of electron-rich phenols and enals providing structurally diverse 4-aryl-3,4-dihydrocoumarins in good to excellent yields and enantioselectivity. This method was useful in the synthesis of natural products and biologically relevant compounds from readily available starting materials.