10.1021/acs.orglett.7b00088.s002
Guo-Tai Li
Guo-Tai
Li
Zhi-Ke Li
Zhi-Ke
Li
Qing Gu
Qing
Gu
Shu-Li You
Shu-Li
You
Asymmetric Synthesis of 4‑Aryl-3,4-dihydrocoumarins by <i>N</i>‑Heterocyclic Carbene Catalyzed Annulation of Phenols with Enals
American Chemical Society
2017
enantioselectivity
Annulation
enal
Phenol
annulation
4-
Carbene
scope
enantioselective synthesis
method
reaction proceeds
Asymmetric Synthesis
heterocyclic carbene
material
Heterocyclic
yield
Aryl
compound
Catalyzed
dihydroisoquinoline-type NHC
DHIQ-NHC
electron-rich phenols
Enal
l-phenylalanine
aryl
2017-02-23 22:03:31
Dataset
https://acs.figshare.com/articles/dataset/Asymmetric_Synthesis_of_4_Aryl-3_4-dihydrocoumarins_by_i_N_i_Heterocyclic_Carbene_Catalyzed_Annulation_of_Phenols_with_Enals/4688527
The
highly enantioselective synthesis of 4-aryl-3,4-dihydrocoumarins
was realized through direct annulation of phenols with enals catalyzed
by dihydroisoquinoline-type NHC (DHIQ-NHC), an <i>N</i>-heterocyclic
carbene derived from l-phenylalanine. The catalytic reaction
proceeds with a wide scope of electron-rich phenols and enals providing
structurally diverse 4-aryl-3,4-dihydrocoumarins in good to excellent
yields and enantioselectivity. This method was useful in the synthesis
of natural products and biologically relevant compounds from readily
available starting materials.