Li, Yi-Jin Yan, Na Liu, Chun-Hua Yu, Yang Zhao, Yu-Long Gold/Copper-Co-catalyzed Tandem Reactions of 2‑Alkynylanilines: A Synthetic Strategy for the C2-Quaternary Indolin-3-ones A new strategy for direct and highly efficient synthesis of 2,3′-bisindolin-3-ones has been developed via a gold/copper-co-catalyzed tandem reactions of 2-alkynylanilines using TBHP as the terminal oxidant and oxygen-atom source. The single-step process involves a novel tandem intermolecular nucleophilic addition, intramolecular cyclization/oxidative cross-dehydrogenative coupling where up to four new bonds and two indole rings were created simultaneously in one-pot manner. The reaction features a broad substrate scope, good functional group tolerance, and high atom-economy. TBHP;reaction features;nucleophilic addition;2- alkynylanilines;intramolecular;bisindolin;substrate scope;cyclization;strategy;Synthetic Strategy;C 2-Quaternary Indolin -3-ones;indole rings;synthesis;atom-economy;oxygen-atom source;novel tandem;terminal oxidant;cross-dehydrogenative;Alkynylaniline;group tolerance;one-pot manner;Tandem;bond 2017-02-20
    https://acs.figshare.com/articles/journal_contribution/Gold_Copper-Co-catalyzed_Tandem_Reactions_of_2_Alkynylanilines_A_Synthetic_Strategy_for_the_C2-Quaternary_Indolin-3-ones/4669042
10.1021/acs.orglett.7b00200.s001