10.1371/journal.pone.0172551.g006
William M. Southern
William M.
Southern
Anna S. Nichenko
Anna S.
Nichenko
Daniel D. Shill
Daniel D.
Shill
Corey C. Spencer
Corey C.
Spencer
Nathan T. Jenkins
Nathan
T. Jenkins
Kevin K. McCully
Kevin K.
McCully
Jarrod A. Call
Jarrod A.
Call
Exercise training-induced effects on mitochondrial biogenesis and maintenance, and potential contraindicative effects of statin use.
Public Library of Science
2017
Male C 57BL wildtype mice
LC 3-II protein content
PGC
ankle plantarflexor contractile assessment
endurance exercise training
vivo fatigue resistance
muscle mitochondrial maintenance
Mitochondrial autophagy-related protein contents
exercised-induced mitochondrial adaptations
simvastatin treatment
citrate synthase activity
6- week regimen
2017-02-16 20:54:48
Figure
https://plos.figshare.com/articles/figure/Exercise_training-induced_effects_on_mitochondrial_biogenesis_and_maintenance_and_potential_contraindicative_effects_of_statin_use_/4663507
<p>Normal mitochondrial maintenance (black arrows) is theoretically characterized by the balance between the addition of healthy mitochondria (mitochondria with white fill) via mitochondrial biogenesis and removal of damaged mitochondria (mitochondrial with red fill) via autophagy. Herein, short-term statin use was associated with a decrease in mitochondrial fission protein Drp1 and altered autophagy-related protein LC3 content, which may contribute to disrupted mitochondrial maintenance. Long-term disruption in the mitochondrial maintenance (red dashed arrow) may lead to accumulation of damaged mitochondria. More directed research is necessary to understand the potential long-term impact of statin use on mitochondrial fission, autophagy, and function.</p>