10.1021/acs.molpharmaceut.6b01008.s001
Robert
C. Deller
Robert
C.
Deller
Paraskevi Diamanti
Paraskevi
Diamanti
Gabriella Morrison
Gabriella
Morrison
James Reilly
James
Reilly
Benjamin C. Ede
Benjamin C.
Ede
Robert Richardson
Robert
Richardson
Kristian Le Vay
Kristian
Le Vay
Andrew M. Collins
Andrew M.
Collins
Allison Blair
Allison
Blair
Adam W. Perriman
Adam W.
Perriman
Functionalized Triblock Copolymer Vectors for the
Treatment of Acute Lymphoblastic Leukemia
American Chemical Society
2017
cationic surface charges
Acute Lymphoblastic Leukemia
efficacy
T-acute lymphoblastic leukemia patient cells
biocompatible triblock copolymer micelles
emulsion-to-micelle transition method
Parthenolide
Functionalized Triblock Copolymer Vectors
lymphoblastic leukemia
particle-based delivery vectors
2017-01-31 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Functionalized_Triblock_Copolymer_Vectors_for_the_Treatment_of_Acute_Lymphoblastic_Leukemia/4659127
The
chemotherapeutic Parthenolide is an exciting new candidate
for the treatment of acute lymphoblastic leukemia, but like many other
small-molecule drugs, it has low aqueous solubility. As a consequence,
Parthenolide can only be administered clinically in the presence of
harmful cosolvents. Accordingly, we describe the synthesis, characterization,
and testing of a range of biocompatible triblock copolymer micelles
as particle-based delivery vectors for the hydrophobic drug Parthenolide.
The drug-loaded particles are produced via an emulsion-to-micelle
transition method, and the effects of introducing anionic and cationic
surface charges on stability, drug sequestration, biocompatibility,
and efficacy are investigated. Significantly, we demonstrate high
levels of efficacy in the organic solvent-free systems against human
mesenchymal stem cells and primary T-acute lymphoblastic leukemia
patient cells, highlighting the effectiveness of the delivery vectors
for the treatment of acute lymphoblastic leukemia.