%0 Journal Article %A Rasu, Loorthuraja %A John, Jeremy M. %A Stephenson, Elanna %A Endean, Riley %A Kalapugama, Suneth %A Clément, Roxanne %A Bergens, Steven H. %D 2017 %T Highly Enantioselective Hydrogenation of Amides via Dynamic Kinetic Resolution Under Low Pressure and Room Temperature %U https://acs.figshare.com/articles/journal_contribution/Highly_Enantioselective_Hydrogenation_of_Amides_via_Dynamic_Kinetic_Resolution_Under_Low_Pressure_and_Room_Temperature/4650319 %R 10.1021/jacs.6b12254.s001 %2 https://ndownloader.figshare.com/files/7583059 %K Low Pressure %K 4 atm H 2 pressure %K system hydrogenates functionalized α- phenoxy %K system trans %K Room Temperature High-throughput screening %K lab-scale optimization %K PrONa %K enantiomeric %K chiral alcohols %K Amide %K Dynamic Kinetic Resolution %K room temperature %K 2- PrOH %K Enantioselective Hydrogenation %K skewpho %K amide %K RuCl %K dpen %X High-throughput screening and lab-scale optimization were combined to develop the catalytic system trans-RuCl2((S,S)-skewphos)­((R,R)-dpen), 2-PrONa, and 2-PrOH. This system hydrogenates functionalized α-phenoxy and related amides at room temperature under 4 atm H2 pressure to give chiral alcohols with up to 99% yield and in greater than 99% enantiomeric excess via dynamic kinetic resolution. %I ACS Publications