%0 Figure %A Joshi, Shilpy %A Davidson, Guillaume %A Le Gras, Stéphanie %A Watanabe, Shuichi %A Braun, Thomas %A Mengus, Gabrielle %A Davidson, Irwin %D 2017 %T Tead-regulated genes in C2C12 cells. %U https://plos.figshare.com/articles/figure/Tead-regulated_genes_in_C2C12_cells_/4632910 %R 10.1371/journal.pgen.1006600.g006 %2 https://ndownloader.figshare.com/files/7648165 %K C 2C cells %K TEAD transcription factor function %K Tead 4 mutants %K Tead 4 inactivation %K PM %K myogenic differentiation genes %K myogenic differentiation %K TEAD transcription factors %K Tead 4 %K Tead 1 %K MCAT %K notexin-induced muscle regeneration %K mouse muscle fibres %K C 2C differentiation %K muscle cell-identity genes %X

A. Schematic outline of the experimental design and box plots showing gene expression changes during differentiation of cells transfected with siTead1/4. B. Examples of genes deregulated in siTead1/4 cells compared to siControl. C. GSEA analyses of Tead1/4 regulated genes. The most significant categories in the up- and down-regulated genes sets are shown. D. Tead4 sites preferentially occupied in differentiated cells and associated with expressed genes are depicted in a read density map alongside a heat hap of gene expression following siTead1/4 knockdown.

%I PLOS Genetics