10.1021/jacs.6b12949.s001
Joseph
K. Awino
Joseph
K.
Awino
Roshan W. Gunasekara
Roshan W.
Gunasekara
Yan Zhao
Yan
Zhao
Sequence-Selective
Binding of Oligopeptides in Water
through Hydrophobic Coding
American Chemical Society
2017
nM
Sequence-Selective
Binding
binding
surface
oligopeptide
nanoparticle
array
nature
research
affinity
side chains
method
location
peptide
micelle
cross-linked
Hydrophobic
Coding
Oligopeptide
sequence-specific
receptor
hydrophobically
2017-01-27 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Sequence-Selective_Binding_of_Oligopeptides_in_Water_through_Hydrophobic_Coding/4600192
A general
method for sequence-specific binding of peptides remains
elusive despite decades of research. By creating an array of “hydrophobically
coded dimples” on the surface of surface–core doubly
cross-linked micelles, we synthesized water-soluble nanoparticle receptors
to recognize peptides by the location, number, and nature of their
hydrophobic side chains. Minute differences in the side chains could
be distinguished, and affinities up to 20 nM were obtained for biologically
active oligopeptides in water.