10.1021/jacs.6b12949.s001 Joseph K. Awino Joseph K. Awino Roshan W. Gunasekara Roshan W. Gunasekara Yan Zhao Yan Zhao Sequence-Selective Binding of Oligopeptides in Water through Hydrophobic Coding American Chemical Society 2017 nM Sequence-Selective Binding binding surface oligopeptide nanoparticle array nature research affinity side chains method location peptide micelle cross-linked Hydrophobic Coding Oligopeptide sequence-specific receptor hydrophobically 2017-01-27 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Sequence-Selective_Binding_of_Oligopeptides_in_Water_through_Hydrophobic_Coding/4600192 A general method for sequence-specific binding of peptides remains elusive despite decades of research. By creating an array of “hydrophobically coded dimples” on the surface of surface–core doubly cross-linked micelles, we synthesized water-soluble nanoparticle receptors to recognize peptides by the location, number, and nature of their hydrophobic side chains. Minute differences in the side chains could be distinguished, and affinities up to 20 nM were obtained for biologically active oligopeptides in water.