10.6084/m9.figshare.4591843.v3
P. Sambasiva Rao
P. Sambasiva
Rao
K. Chinna Ashalu
K. Chinna
Ashalu
G. Jitender Dev
G. Jitender
Dev
N. Ravi Kumar
N. Ravi
Kumar
P. V. S. S. Srinivas
P. V. S. S.
Srinivas
B. V. Thomas
B. V.
Thomas
B. Narsaiah
B.
Narsaiah
Efficient method for the synthesis of 1,2,3-triazole functionalized isoxazolidine derivatives by 1,3-dipolar cycloaddition of nitrones with terminal olefins
Taylor & Francis Group
2017
1,3-Dipolar cycloaddition
isoxazolidine
nitrones
olefins
1,2,3-triazole
2017-02-15 19:37:42
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Efficient_method_for_the_synthesis_of_1_2_3-triazole_functionalized_isoxazolidine_derivatives_by_1_3-dipolar_cycloaddition_of_nitrones_with_terminal_olefins/4591843
<p>1-Phenyl-1,2,3-triazole-4-carbaldehyde <b>1</b> was treated with different <i>N</i>-alkyl hydroxylamine hydrochlorides <b>2</b> using NaHCO<sub>3</sub> to obtain 1,2,3-triazole substituted <i>N</i>-alkyl nitrones <b>3a–c</b>. The nitrones <b>3a–c</b> were further reacted with different substituted olefins and furnished 2-alkyl-3-(1-phenyl-1<i>H</i>-1,2,3-triazol-4-yl)-5-(substituted)isoxazolidine derivatives <b>4a–p</b> in high yields via 1,3-dipolar cycloaddition reaction.</p>