10.6084/m9.figshare.4584283.v2
Mandipogula Mahesh
Mandipogula
Mahesh
Veladi Panduranga
Veladi
Panduranga
Girish Prabhu
Girish
Prabhu
Roopesh Kumar L
Roopesh Kumar
L
P. Venkata Ramana
P. Venkata
Ramana
Vommina V. Sureshbabu
Vommina V.
Sureshbabu
Oxidative amidation of benzyl alcohols with amino acid esters mediated by <i>N</i>-hydroxysuccinimide/phenyliodine diacetate
Taylor & Francis Group
2017
Amide
benzyl alcohol and amino acid
N-hydroxysuccinimide
oxidation
phenyliodine diacetate
2017-03-17 16:22:11
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Oxidative_Amidation_of_Benzyl_Alcohols_with_Amino_Acid_Esters_Mediated_by_N-hydroxysuccinimide_phenyliodine_Diacetate/4584283
<p>A simple protocol involving metal-free oxidative amidation of benzyl alcohols with amino acid esters has been presented. The amidation proceeds in a radical pathway unlike in conventional metal-mediated extrusion of dihydrogen. The method is advantageous in terms of metal-free conditions, nonexpensive commercial starting substrates. Also various substituents in the starting materials are tolerated and sterically hindered amino acid side chains could provide good yields of amide products.</p>